American scientists from the University of Illinois at Chicago have identified an important mechanism of blood aging – a decrease in the level of a protein known as platelet factor 4 (PF4). The results of their study were published in the journal Blood.
According to the specialists, with age, the concentration of PF4 decreases, leading to a deterioration in the function of bone marrow stem cells. This, in turn, increases the risk of inflammatory processes, blood cancers, and cardiovascular problems.

The scientists noted that in a young body, PF4 controls the division of hematopoietic stem cells and prevents their excessive proliferation. However, with age, this control weakens: cells begin to divide more frequently, accumulate genetic mutations, and lose the ability to produce full-fledged lymphocytes, which weakens the immune system.
Researchers consider PF4 a kind of “elixir of youth.” However, they believe it should only be used as part of a comprehensive therapy aimed at restoring blood function and strengthening the immune system.
As a reminder, we previously reported on the creation of superglue that instantly fuses human bones.
To be continued…



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